{"id":1670,"date":"2019-08-02T14:48:32","date_gmt":"2019-08-02T12:48:32","guid":{"rendered":"https:\/\/projects.lne.eu\/jrp-edc-wfd\/?page_id=1670"},"modified":"2023-11-17T16:42:10","modified_gmt":"2023-11-17T16:42:10","slug":"wp2","status":"publish","type":"page","link":"https:\/\/projects.lne.eu\/jrp-neurobiostand\/wp2\/","title":{"rendered":"WP2: Standardisation of NfL in blood"},"content":{"rendered":"<p>The aim of this work package is to standardise the measurement of the non-specific marker for neurodegeneration and axonal damage: neurofilamentlight chain (NfL).<br \/>\nTask 2.1 will define what the target analyte is in a matrix (plasma or serum) and develop a reference measurement procedure by isotope dilution mass spectrometry (IDMS) for quantification of neurofilament in plasma or serum with a target uncertainty below 15 %.<br \/>\nTask 2.2 will explore the development of matrix-based prototype RMs and assess the commutability of those with available measurement techniques.<br \/>\nTask.2.3 will develop a routine, clinical LC-MS assay, allowing uptake of the RMP in clinical practice. Patient data will be correlated with analytical measurements with a potential to uncover new aspects of NfL that may aid patient stratification.<\/p>\n<p><strong><span style=\"color: #0000ff\">WP leader: Christopher Hopley, Emanuele Scollo, Eva Illes-Toth (LGC limited)<\/span><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The aim of this work package is to standardise the measurement of the non-specific marker for neurodegeneration and axonal damage: neurofilamentlight chain (NfL). Task 2.1 will define what the target analyte is in a matrix (plasma or serum) and develop a reference measurement procedure by isotope dilution mass spectrometry (IDMS) for quantification of neurofilament in [&hellip;]<\/p>\n","protected":false},"author":10,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","footnotes":""},"class_list":{"0":"post-1670","1":"page","2":"type-page","3":"status-publish","5":"entry","6":"gs-1","7":"gs-odd","8":"gs-even","9":"gs-featured-content-entry"},"acf":[],"_links":{"self":[{"href":"https:\/\/projects.lne.eu\/jrp-neurobiostand\/wp-json\/wp\/v2\/pages\/1670"}],"collection":[{"href":"https:\/\/projects.lne.eu\/jrp-neurobiostand\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/projects.lne.eu\/jrp-neurobiostand\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/projects.lne.eu\/jrp-neurobiostand\/wp-json\/wp\/v2\/users\/10"}],"replies":[{"embeddable":true,"href":"https:\/\/projects.lne.eu\/jrp-neurobiostand\/wp-json\/wp\/v2\/comments?post=1670"}],"version-history":[{"count":2,"href":"https:\/\/projects.lne.eu\/jrp-neurobiostand\/wp-json\/wp\/v2\/pages\/1670\/revisions"}],"predecessor-version":[{"id":2031,"href":"https:\/\/projects.lne.eu\/jrp-neurobiostand\/wp-json\/wp\/v2\/pages\/1670\/revisions\/2031"}],"wp:attachment":[{"href":"https:\/\/projects.lne.eu\/jrp-neurobiostand\/wp-json\/wp\/v2\/media?parent=1670"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}