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NEuroBioStand

A LNE Joint Research Project

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  • Project Overview
  • Workpackages
    • WP1: Standardisation of blood-based measurements of P-tau
    • WP2: Standardisation of NfL in blood
    • WP3: Metrological strategies for emerging biomarkers measurements and protein conformational states
    • WP4: Creating impact
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Neurodegenerative disorders (NDDs) affect over nine million Europeans and constitute a large economic burden to society. NDD biomarkers have transformed the research landscape by linking diseases to pathological processes and assisting drug development. NDD biomarkers improve the accuracy of diagnosis and prognosis with the use of non-invasive tools. However, their implementation in clinical practice is hampered by a lack of standardisation. This project will build on the knowledge and experience of EMPIR projects 15HLT04 NeuroMet, 18HLT09 NeuroMET2 and 18HLT10 CardioMet and the International Federation of Clinical Chemistry (IFCC) programme to standardise biomarker measurements, harmonise measurements across assay manufacturers as well as develop and implement new biomarkers.

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The project

22HLT07 NEuroBioStand has been selected under the EPM (European Partnership on Metrology) programme.

European Partnerships are a key implementation tool of the European Commission’s Horizon Europe; an ambitious research and innovation programme, running from 2021 to 2027.

The European Partnership on Metrology is co-funded by the Member States and the European Union with an expected budget of around 690 million euro. The expected impact of the European Partnership on Metrology is manifold, as it will support a wide range of policies, commerce and advancement of key European challenges.

The Partnership builds on the progress achieved under the previous European Metrology Research Programmes, and aims to break new ground by contributing to the development of self-sustaining, coordinated metrology infrastructures, with the capacity to continue joint research and innovation after 2030.

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Workpackages

This project will develop a metrological research framework for standardising biomarkers of neurodegenerative diseases (NDDs), including Alzheimer’s disease, dementia with Lewy bodies, frontotemporal dementia and Parkinson’s disease, the fast implementation and commercialisation of promising assays for NDD biomarkers will be promoted through compliance to the EU IVDR 2017/746.

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PARTICIPATING EURAMET NMIs AND DIs and their associated partners

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CLINICIANS AND ACADEMIC PARTICIPANTS


INDUSTRIAL PARTICIPANTS
ADx Neurosciences - State-of-the-art biomarker assays


The project (22HLT07 NEuroBioStand) has received funding from the European Partnership on Metrology, co-financed from the European Union’s Horizon Europe Research and Innovation Programme and by the Participating States.

Funded by the European Union. Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or EURAMET. Neither the European Union nor the granting authority can be held responsible for them.

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News

M9 Consortium meeting and Symposium on Biomarkers in Neurodegenerative Diseases in Montpellier

IFCC WorldLab 2024 Dubai

Presentation of the NEuroBioStand project at FAAST

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