The aim of this work package is to progress measurement for emerging biomarkers and novel approaches for protein structural conformation determination.
Task 3.1 will be devoted to GFAP, as an emerging biomarker candidate and the objective of the work will be to promote its implementation in clinical practice by developing a LC-MS to evaluate the feasibility for SI-traceable quantification in biological fluids.
Task 3.2 will address the development of MS-based approaches to monitor the conformational state of proteins involved in neurodegeneration, namely tau and GFAP, through the use of native mass spectrometry and cross-linking coupled to mass spectrometry.

WP leader: Dr. Chiara Giangrande (LNE)